Background: Chlorhexidine is the gold standard of dental plaque prevention. The aim of the present study was to\ncompare the plaque and gingivitis inhibiting effect of commercial products containing 0.2%, 0.12% and 0.06%\nchlorhexidine in a modified experimental gingivitis model.\nMethods: In three groups of healthy volunteers, experimental gingivitis was induced and monitored over 21 days\nand simultaneously treated with the commercial solutions containing 0.2%, 0.12% and 0.06% chlorhexidine. The\nmaxillary right quadrant of each individual received mouthwash only, whereas the maxillary left quadrant was\nsubject to both rinsing and mechanical oral hygiene. Compliance and side effects were monitored at days 7, 14,\nand 21. Plaque and gingivitis scores were obtained at baseline and day 21.\nResults: The commercial mouthwash containing 0.2% chlorhexidine resulted in statistically significantly lower plaque\nscores than the 0.12 and 0.06% mouthwashes after 21 days use, whereas no statistically significant difference was\nfound between the effects of the two latter.\nConclusion: A commercially available mouthwash containing 0.2% chlorhexidine had statistically significant better\neffect in preventing dental plaque than the 0.12% and 0.06% solutions
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